مدل‌سازی و بررسی رفتار DNA اوریگامی مثلثی تحت تأثیر دمای آزمایشگاهی

نوع مقاله : مقاله علمی

نویسندگان
1 دانشجوی دکتری؛ فنی و مهندسی، مهندسی مکانیک، دانشگاه فردوسی مشهد، مشهد، ایران
2 دانشیار؛ فنی و مهندسی، مهندسی مکانیک، دانشگاه حکیم سبزواری، سبزوار، ایران
چکیده
در این مقاله، رفتار مکانیکی DNA اوریگامی مثلثی که دارای مشخصات ظاهری و عملکرد ویژه‌ای می‌باشد، مورد بررسی قرار گرفته است. DNA اوریگامی مثلثی را می‌توان به عنوان یک نانو‌وسیله‌ی دارای چند درجه‌ی آزادی معرفی کرد. برای بررسی این موضوع، مدل‌سازی و شبیه‌سازی دینامیک مولکولی انجام شده است و سپس به تحلیل عملکرد آن پرداخته می‌شود. اولین گام در شناخت یک نانو‌وسیله تحلیل ساختاری آن می‌باشد. در این گزارش، تغییرات ساختاری نانو‌وسیله در اثر تغییر دما مورد بررسی قرار گرفته است. نتایج نشان می‌دهد میزان تغییرات ساختاری تقریباً در 800 پیکوثانیه به کمترین میزان خود رسیده است. پس از طی این بازه‌ی زمانی می‌توان گفت DNA اوریگامی مثلثی نسبتاً به ثبات ساختاری رسیده است. رفتار مکانیکی DNA اوریگامی به‌ صورتی خواهد بود که آن را برای گرفتن حجم متفاوتی از محموله‌ها مناسب می‌کند. به‌عبارتی، از آن می‌توان برای حمل نانوداروهایی با ابعاد متنوع استفاده کرد. درواقع، پارامتری که در این نانو‌وسیله‌ بسیار جالب‌توجه است، انعطاف‌پذیری بازوهای آن است. این انعطاف‌پذیری می‌تواند به‌طور شایسته‌ای برای حمل انواع مختلفی از محموله‌ها مورد استفاده قرار گیرد.  
کلیدواژه‌ها
موضوعات

عنوان مقاله English

Modeling and investigating the behavior of triangular origami DNA under the influence of laboratory temperature

نویسندگان English

Sadegh Dastorani 1
Reza Hasanzadeh Ghasemi 2
1 PhD candidate, Department of Mechanical Engineering, Ferdowsi University of Mashhad, Iran.
2 Associate Professor, Department of Mechanical Engineering, Hakim Sabzevari University, Iran.
چکیده English

In this article, the mechanical behavior of triangular origami DNA, which has special appearance and functional characteristics, has been investigated. Triangular origami DNA can be introduced as a Nano-device with several degrees of freedom. To investigate this issue, molecular dynamics modeling and simulation have been done and then its performance is analyzed. The first step in knowing a Nano-device is its structural analysis. In this report, the structural changes of the Nano-device due to the change in temperature have been investigated the results show that the amount of structural changes has reached its lowest level in approximately 800 picoseconds. After this period of time, it can be said that the triangular origami DNA has relatively reached structural stability. The mechanical behavior of origami DNA will be such that it is suitable for taking different volumes of cargo. In other words, it can be used to carry Nano drugs with various dimensions. In fact, the most interesting parameter in this Nano-device is the flexibility of its arms. This flexibility can be properly used to carry different types of cargo.

کلیدواژه‌ها English

Mechanical behavior
Molecular dynamics simulation
Origami DNA
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